Everything About Cannabinoids

Cannabinoids are the chemicals in the resin of the cannabis plant. However, they also occur in the bodies of humans and animals and are called endocannabinoids.

To understand cannabinoids you have to know a little about the endocannabinoid system.

The endocannabinoids are naturally formed in the body. It is in fact the body’s own cannabinoid system.

The human body makes substances that are very similar to cannabis-like substances. So much so, that the body recognizes cannabis as the body’s own. These substances are called endocannabinoids.

A well-known endocannabinoid is anandamine, a neurotransmitter that affects the feeling of hunger or memory.

The human body contains cannabinoid receptors that can connect with cannabinoids such as CBD and THC. The receptors are located on cells and act as a sort of antenna that receives and transmits signals. If a receptor has received a signal, it is guided to the right place by the cell after which a reaction occurs.

After binding with a specific receptor, certain cannabinoids can influence all kinds of reaction in the body and stimulate the immune system.

There are estimated to be hundreds of cannabinoids that have characteristic properties that improve health.

CBD – one of the best known – is the most special, naturally occurring cannabinoid. It can contribute to a better balance of body and mind.

To obtain CBD, industrial hemp plants are grown on a large scale by the name Sativa L. In these industrial hemp almost no THC occurs. THC is the psychoactive cannabinoid.

The Dutch government has determined that only a very small amount of THC may occur in CBD. Renviden meets that standard.

As mentioned there are estimated to be hundreds of cannabinoids that offer health benefits. The most well-known are CBD and THC, but we like to mention a number of other important cannabinoids below. You can also download the document in the download section.

Cannabichromene Acid CBC-A: anti-inflammatory, anti-fungal, highly antibacterial.

Cannabichromene CBC:  anxiety and stress, anti-inflammatory, analgesic, antimicrobial, antiviral, inhibits tumor cell growth, stimulates bone growth, helps narrow blood vessels.

Cannabinol Acid CBN-A: anti-inflammatory.

Cannabinol CBN: very slightly psychoactive, helps with insomnia, effective as antioxidant, anti-cramp, reduces nausea, reduces epileptic seizure, more calming than other cannabinoids.

Cannabidiol Acid CBD-A: anti-inflammatory, anti-tumor.

Cannabidiol CBD:  not psychoactive, reduces epileptic seizures, lowers blood sugar levels, anti-psychotic, anti-inflammatory, analgesic, anti-cramp, promotes sleep, neuro-protective, antibacterial, promotes bone growth, reduces anxiety, anti-tumor, reduces nausea.

Cannabidivarin CBDV: stimulates bone growth.

Cannabigerol Acid CBG-A: is considered the mother of the cannabinoids from which all other cannabinoids originate. Rare medicinal compound for neuro-regenerative diseases.

Cannabigerol CBG: not psychoactive, stimulates the growth of new brain cells, well applicable in the elderly,  stimulates bone growth, is antibacterial, anti-tumor, anti-inflammatory, antidepressant, insomnia, reduces pressure eyeball.

Tetrahydrocannabinolic Acid: THC-A is a non-psychoactive acid precursor of THC, reduces anxiety, depression, works anti-inflammatory, helps with anorexia, pain, IBS / Crohn, spasticity, attacks (neuromuscular), stimulates bone growth, helps with nausea, anti-tumor, anti-spasm, stimulates appetite.

Tetrahydrocannabinol: THC psychoactive, analgesic, anti-inflammatory, promotes sleep, reduces sleep apnea, euphoric, reduces nausea, stimulates appetite, anti-tumor, antidepressant, anti-cramp, reduces eye pressure, stimulates bone growth, neuroprotective, antioxidant, calming.

Tetrahydrocannabinol Delta 8: Δ 8-THC: works anti-inflammatory, stimulates appetite, pain relief and neuro-protective.

Tetrahydrocannabivarin: THCV  psychoactive effects, reduces epileptic seizures, gives energy, regulates sugar levels, reduces panic attacks, can help Alzheimer’s, stimulates the growth of bones and can be helpful in osteoporosis.

Also check the extensive cannabinoid overview in the section Full Spectrum Extract.

Endocannabinoids

The human body makes substances that are very similar to cannabis-like substances. So much so, that the body recognizes cannabis as the body’s own. These substances are called endocannabinoids, the body’s own cannabinoid system.

Endocannabinoids are of great importance for the normal functioning of the body. They are made by our body and control our immune system and all of our organs. They have a big influence on our immune system and therefore on the balance and imbalance of our body and the related syndromes.

Phytocannabinoids

Phytocannabinoids, in short cannabinoids, are vegetable cannabinoids from the industrial hemp plant. Phyto = plant.

They are also called natural, herbal or classic cannabinoids. They bind to receptors in the body: in the brain, nervous system and immune system.

Up till now cannabinoids have not been found in any other plant and for the time being the hemp plant is the only plant that contains phytocannabinoids; a substance that resembles our endocannabinoids like two drops of water.

The most abundant phytocannabinoids found in the industrial hemp plant are tetrahydrocannabinol (THC) and cannabidiol (CBD). But there are hundreds of phytocannabinoids.

Because of the increased interest in the useful qualities phytocannabinoids possesses, they are currently being studied on a large scale all over the world.

Find more information in the section “What are cannabinoids” and the section “Endocannabinoid system”.

There are hundreds of cannabinoids. This is an overview of the most well-known:

Cannabichromene Acid CBC-A: anti-inflammatory, anti-fungal, highly antibacterial.

Cannabichromene CBC:  anxiety and stress, anti-inflammatory, analgesic, antimicrobial, antiviral, inhibits tumor cell growth, stimulates bone growth, helps narrow blood vessels.

Cannabinol Acid CBN-A: anti-inflammatory.

Cannabinol CBN: very slightly psychoactive, helps with insomnia, effective as antioxidant, anti-cramp, reduces nausea, reduces epileptic seizure, more calming than other cannabinoids.

Cannabidiol Acid CBD-A: anti-inflammatory, anti-tumor.

Cannabidiol CBD:  not psychoactive, reduces epileptic seizures, lowers blood sugar levels, anti-psychotic, anti-inflammatory, analgesic, anti-cramp, promotes sleep, neuro-protective, antibacterial, promotes bone growth, reduces anxiety, anti-tumor, reduces nausea.

Cannabidivarin CBDV: stimulates bone growth.

Cannabigerol Acid CBG-A: is considered the mother of the cannabinoids from which all other cannabinoids originate. Rare medicinal compound for neuro-regenerative diseases.

Cannabigerol CBG: not psychoactive, stimulates the growth of new brain cells, well applicable in the elderly,  stimulates bone growth, is antibacterial, anti-tumor, anti-inflammatory, antidepressant, insomnia, reduces pressure eyeball.

Tetrahydrocannabinolic Acid: THC-A is a non-psychoactive acid precursor of THC, reduces anxiety, depression, works anti-inflammatory, helps with anorexia, pain, IBS / Crohn, spasticity, attacks (neuromuscular), stimulates bone growth, helps with nausea, anti-tumor, anti-spasm, stimulates appetite.

 Tetrahydrocannabinol: THC psychoactive, analgesic, anti-inflammatory, promotes sleep, reduces sleep apnea, euphoric, reduces nausea, stimulates appetite, anti-tumor, antidepressant, anti-cramp, reduces eye pressure, stimulates bone growth, neuroprotective, antioxidant, calming.

Tetrahydrocannabinol Delta 8: Δ 8-THC: works anti-inflammatory, stimulates appetite, pain relief and neuro-protective.

Tetrahydrocannabivarin: THCV  psychoactive effects, reduces epileptic seizures, gives energy, regulates sugar levels, reduces panic attacks, can help Alzheimer’s, stimulates the growth of bones and can be helpful in osteoporosis.

EXPLANATION OF THE ENDOCANNABINOID SYSTEM

The endocannabinoid system (ECS) is a body-specific system that consists of a group of endogenous cannabinoids receptors in the brain and in the entire central and peripheral nervous system of the body.

Receptors are literally recipients of messages, signals. They act as chemical substances and bind to the receptor. Each message then creates a certain effect in the body.

That’s why the ECS is so crucial to proper functioning and health. Dysregulation of the ECS contributes to a wide variety of conditions that prevent the body from achieving balance. If the ECS isn’t functioning correctly, your body has a difficult time regulating emotions, appetite, memory, and everything else the ECS is responsible for.

Two primary endocannabinoid receptors have already been identified: CB1 receptor and CB2 receptor. 

Cannabinoid Receptor 1 (CB1) is mainly found in our nervous system, brain, spinal cord, lungs, liver and kidneys. In our brains they mainly occur in parts that control functions such as body temperature, emotion, memory, learning, perception of feeling, movement and coordination.

CB1 receptors are also involved in the management of hormonal functions in our brains. Functions such as sleep, pain, appetite, memory and perception are also influenced by CB1 receptors.

Because of the similar molecular structure our natural endocannabinoids and the cannabinoid THC bind mainly with CB1. It relieves pain, nausea and depression.

The two most well-known endocannabinoids are Anandamine (AEA) and 2-Arachidonylglycerol (2-AG). The endocannabinoid Anandamine binds to the CB1 receptors just like THC.

CB2 receptor is mainly found in the immune system and the peripheral structures (our arms and legs), the spleen and the gastrointestinal system (stomach and int

The endocannabinoid system (ECS) is a body-specific system that consists of a group of endogenous cannabinoids receptors in the brain and in the entire central and peripheral nervous system of the body. You could say the ECS is your body’s own cannabinoid system. It was discovered by Prof. Dr. Raphael Mechoulam.

The human body produces substances that are very similar to cannabis-like substances. So much so, that the body recognizes cannabis as the body’s own. These substances are called endocannabinoids.

This ECS has a very important function in our body. It is responsible for regulating an array of physiological processes that are instrumental in maintaining health.

Although in the 19th century scientists were already familiar with the cannabinoid CBN (cannabinol) and around 1930 with the cannabinoid CBD (cannabidiol), it was 30 years later that Prof. Mechoulam isolated and identified the psychoactive cannabinoid tetrahydrocannabinol (THC). He and his team had previously identified the chemical structure of cannabidiol (CBD).

The cannabinoid research was in full swing. In the nineties Prof. Mechoulam and his team located and identified two of the body’s naturally produced major endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG). Anandamine plays a role in pain, depression, memory, fertility and hunger. 2-AG is present at relatively high levels in the central nervous system.

Discovering the presence of an endocannabinoid system, which regulates homeostasis (balance) in the human body was a breakthrough and opened the door for many therapeutic cannabinoid solutions.

When the ECS works properly it helps regulate processes like sleep, appetite, digestion, mood, motor control, immune function, reproduction and fertility, pleasure and reward, memory, temperature regulation, and pain.

When the ECS is disrupted and gets confused because the body fails to produce enough endocannabinoids, you can develop a disease or disorders. In these cases, supplementing with plant cannabinoids may be beneficial.

Research has shown that the system will also recognize and respond to cannabinoids from external sources, including the phytocannabinoid cannabidiol (CBD).

The video “Visualization of the endocannabinoid signaling system” will give you a good insight of how this system works.estines). This type of receptors affects the functioning of the immune system and plays a role in pain (perception), inflammation and tissue damage.

The endocannabinoid 2-AG and the cannabidiol CBD bind best with CB2 receptors.

By assisting your immune system, CBD can help your body combat infections.

The video is part of a Master’s Research Project submitted for Masters of Science Faculty of Medicine, University of Toronto. It has been developed in collaboration with Biomedical Communications, Department of Biology, University of Toronto at Mississauga, The Canadian Consortium for the Investigation of Cannabinoids and with funding provided in part by the Quebec Pain Research Network.

  • Read more on this website under Receptors of the Endocannabinoid System and watch the video on ECS and ECS receptors
  • Read more on this website Under Prof. Dr. Raphael Mechoulam

RECEPTORS ENDOCANNABINOID SYSTEM

The endocannabinoid system (ECS) is a body-specific system that consists of a group of endogenous cannabinoids receptors in the brain and in the entire central and peripheral nervous system of the body.

Receptors are literally recipients of messages, signals. They act as chemical substances and bind to the receptor. Each message then creates a certain effect in the body.

That’s why the ECS is so crucial to proper functioning and health. Dysregulation of the ECS contributes to a wide variety of conditions that prevent the body from achieving balance. If the ECS isn’t functioning correctly, your body has a difficult time regulating emotions, appetite, memory, and everything else the ECS is responsible for.

Two primary endocannabinoid receptors have already been identified: CB1 receptor and CB2 receptor. 

Cannabinoid Receptor 1 (CB1) is mainly found in our nervous system, brain, spinal cord, lungs, liver and kidneys. In our brains they mainly occur in parts that control functions such as body temperature, emotion, memory, learning, perception of feeling, movement and coordination.

CB1 receptors are also involved in the management of hormonal functions in our brains. Functions such as sleep, pain, appetite, memory and perception are also influenced by CB1 receptors.

Because of the similar molecular structure our natural endocannabinoids and the cannabinoid THC bind mainly with CB1. It relieves pain, nausea and depression.

The two most well-known endocannabinoids are Anandamine (AEA) and 2-Arachidonylglycerol (2-AG). The endocannabinoid Anandamine binds to the CB1 receptors just like THC.

CB2 receptor is mainly found in the immune system and the peripheral structures (our arms and legs), the spleen and the gastrointestinal system (stomach and intestines). This type of receptors affects the functioning of the immune system and plays a role in pain (perception), inflammation and tissue damage.

The endocannabinoid 2-AG and the cannabidiol CBD bind best with CB2 receptors.

By assisting your immune system, CBD can help your body combat infections.

Scientists are currently making progress in the field of a third type of cannabinoid receptor for CBN, a non-psychoactive cannabinoid. As soon as research is at a convincing level, we will publish this on our website.

Watch the video of Prof. Dr. Raphael Mechoulam on the endocannabinoid system and ECS receptors.

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